26 results
Children’s exposure to television advertising of unhealthy foods and beverages across four countries of WHO European Region
- Anna V Kontsevaya, Asiia E Imaeva, Yulia A Balanova, João J Breda, Kremlin Wickramasinghe, Jo Martin Jewell, Shynar Abdrakhmanova, Andrew G Polupanov, Tulay Bagci Bosi, Toker Ergüder, Oksana M Drapkina, Emma J Boyland
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- Journal:
- Public Health Nutrition / Volume 26 / Issue S1 / December 2023
- Published online by Cambridge University Press:
- 13 March 2023, pp. s32-s40
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Objective:
To compare the frequency and healthfulness of foods being advertised to children and adolescents in four countries of WHO European region.
Design:Cross-sectional quantitative study, guided by an adapted version of the WHO protocol. All recorded food advertisements were categorised by categories and as either ‘permitted’ or ‘not permitted’ for advertising to children in accordance with WHO Regional Office for Europe Nutrient Profile Model.
Settings:Four countries: Russia, Turkey, Kazakhstan and Kyrgyzstan
Participants:TV channels most popular among children and adolescents
Results:Analysis included 70 d of TV broadcasting for all channels, during which time there were 28 399 advertisements. The mean number of advertisements per hour varied from eleven in Turkey and Kazakhstan to eight and two in Russia and Kyrgyzstan. In all countries, the majority of the food and beverages advertised should not be permitted for advertising to children according to the WHO Nutrient Profile Model. The mean number of non-permitted food and beverage advertisements per hour was high in Turkey and Kazakhstan (8·8 and 8·5 ads) compared with Russia (5·1) and Kyrgyzstan (1·9). Turkey was the only country where nutritional information was fully available, and no values were missing that prevented coding for some product categories.
Conclusions:Results revealed that children and adolescents in four countries are exposed to a considerable volume of food and beverage advertisements, including sugary products on broadcast television. As such, policymakers should consider protecting youth by developing regulations to restrict these marketing activities within media popular with children.
Characterization of instability mechanisms on sharp and blunt slender cones at Mach 6
- Richard E. Kennedy, Joseph S. Jewell, Pedro Paredes, Stuart J. Laurence
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- Journal of Fluid Mechanics / Volume 936 / 10 April 2022
- Published online by Cambridge University Press:
- 17 February 2022, A39
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Experiments are performed to investigate the effect of nose-tip bluntness on the instability mechanisms leading to boundary-layer transition on a $7^{\circ }$ half-angle cone in a Mach-6 free stream. The development of disturbances is characterized using a combination of high-speed calibrated schlieren images and pressure measurements, and the data are compared with results computed using the parabolized stability equations. The approximately 414 mm long cone model is equipped with an interchangeable nose tip ranging from sharp to 5.08 mm in radius. For nose tips with a radius $R_{N}<2.54\ {\rm mm}$, second-mode instability waves are the dominant mechanism leading to transition. Time-averaged frequency spectra computed from the calibrated schlieren visualizations and pressure measurements are used to compute the second-mode most-amplified frequencies and integrated amplification rates ($N$ factors). Good agreement is observed between the measurements and computations in the linear-growth regime for the sharp-nose configuration at each free-stream condition. Additionally, a bispectral analysis identifies quadratic phase locking of frequency content responsible for the growth of higher harmonics. For nose tips of $R_{N}\geqslant 2.54\ {\rm mm}$, the schlieren visualization region is upstream of the entropy-layer swallowing length, and second-mode waves are no longer visible within the boundary layer; instead, elongated, steeply inclined features believed to be associated with non-modal instability mechanisms develop between the entropy-layer and boundary-layer edges. Simultaneously acquired surface pressure measurements reveal high-frequency pressure oscillations similar to second-mode instability waves associated with the trailing edge of these non-modal features.
Placebo response in treatment resistant depression: a systematic review and meta-analysis of multiple treatment modalities
- Brett D M Jones, Cory R. Weissman, Jewel Karbi, Tya Vine, Louise S. Mulsant, Benoit Mulsant, Andre Brunoni, M. Ishrat Husain, Lais B. Razza, Daniel Blumberger, Zafiris J Daskalakis
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- Journal:
- BJPsych Open / Volume 7 / Issue S1 / June 2021
- Published online by Cambridge University Press:
- 18 June 2021, pp. S261-S262
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Aims
The placebo response in depression clinical trials is a major contributing factor for failure to establish the efficacy of novel and repurposed treatments. However, it is not clear as to what the placebo response in treatment-resistant depression (TRD) patients is or whether it differs across treatment modalities. Our objective was to conduct a systematic review and meta-analysis of the magnitude of the placebo response in TRD patients across different treatment modalities and its possible moderators.
MethodSearches were conducted on MEDLINE and PsychInfo from inception to January 24, 2020. Only studies that recruited TRD patients and randomization to a placebo (or sham) arm in a pharmacotherapy, brain stimulation, or psychotherapy study were included (PROSPERO 2020 CRD42020190465). The primary outcome was the Hedges’ g for the reported depression scale using a random-effects model. Secondary outcomes included moderators assessed via meta-regression and response and remission rate. Heterogeneity was evaluated using the Egger's Test and a funnel plot. Cochrane Risk of Bias Tool was used to estimate risks.
Result46 studies met our inclusion criteria involving a total of 3083 participants (mean (SD) age: 45.7 (6.2); female: 52.4%). The pooled placebo effect for all modalities was large (N = 3083, g = 1.08 ,95% CI [0.95-1.20)I 2 = 0.1). The placebo effect in studies of specific treatment modalities did not significantly differ: oral medications g = 1.14 (95%CI:0.99-1.29); parenteral medications g = 1.32 (95%CI:0.59-2.04); ayahuasca g = 0.47 (95%CI:-0.28-1.17); rTMS g = 0.93 (95%CI:0.63-1.23); tDCS g = 1.32 (95%CI:0.52-2.11); invasive brain stimulation g = 1.06 (95%CI:0.64-1.47). There were no psychotherapy trials that met our eligibility criteria. Similarly, response and remission rates were comparable across modalities. Heterogeneity was large. Two variables predicted a lager placebo effect: open-label prospective design (B:0.32, 95%CI: 0.05-0.58; p:0.02) and sponsoring by a pharmaceutical or medical device company (B:0.39, 95%CI:0.13-0.65, p:0.004)). No risk of publication bias was found.
ConclusionThe overall placebo effect in TRD studies was large (g = 1.08) and did not differ among treatment modalities. A better understanding of the placebo response in TRD will require: standardizing the definition of TRD, head-to-head comparisons of treatment modalities, an assessment of patient expectations and experiences, and standardized reporting of outcomes.
Improving the composition and marketing of commercial baby foods: a Nutrient Profile Model
- J.E. Cade, J. Hutchinson, H. Rippin, D. Threapleton, A. Morpeth, J. Jewell, K. Wickramasinghe, J. Breda
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- Journal:
- Proceedings of the Nutrition Society / Volume 80 / Issue OCE1 / 2021
- Published online by Cambridge University Press:
- 30 April 2021, E28
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Inequalities in education and national income are associated with poorer diet in Europe: pooled analysis across 12 countries
- H. L. Rippin, J. Hutchinson, D. C. Greenwood, J. Jewell, J.J. Breda, A. Martin, D. M. Rippin, K. Schindler, P. Rust, S. Fagt, J. Matthiessen, E. Nurk, K. Nelis, M. Kukk, H. Tapanainen, L. Valsta, T. Heuer, E. Sarkadi-Nagy, M. Bakacs, S. Tazhibayev, T. Sharmanov, I. Spiroski, M. Beukers, C. van Rossum, M. Ocke, A. K. Lindroos, Eva Warensjö Lemming, J. E. Cade
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- Proceedings of the Nutrition Society / Volume 80 / Issue OCE1 / 2021
- Published online by Cambridge University Press:
- 30 April 2021, E16
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The extent and nature of television food advertising to children and adolescents in the Russian Federation
- AV Kontsevaya, AE Imaeva, YA Balanova, AV Kapustina, J Breda, JM Jewell, ER Salakhov, OM Drapkina, E Boyland
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- Journal:
- Public Health Nutrition / Volume 23 / Issue 11 / August 2020
- Published online by Cambridge University Press:
- 27 May 2020, pp. 1868-1876
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Objective:
To assess the frequency, healthfulness and promotional techniques of television food advertising to children and adolescents in the Russian Federation.
Design:A cross-sectional study was conducted to monitor food and beverage television advertising. For the five most popular TV channels among children and adolescents, TV broadcasts were recorded for two weekdays and two weekends (320 h) during March–May 2017. Recordings were screened for advertisements. Food advertisements were categorised by food categories and as either ‘permitted’ or ‘not permitted’ for advertising to children in accordance with World Health Organization Regional Office for Europe Nutrient Profile Model (NPM), and promotional techniques in advertisements were recorded.
Results:Overall, 11 678 advertisements were coded. Across all channels, food and drink (19·2 %) were the most frequently advertised product type. The most common food categories advertised were beverages (except juices, milk drinks and energy drinks) (24·1 %); yoghurts and other dairy foods (15 %); and chocolate and confectionery (12·3 %). A majority (64·2 %) of food and drink products advertised should not be permitted for advertising to children according to the NPM. The most frequently used persuasive appeals in the food advertisements were low price (15·4 %), product novelty (11·8 %) and enjoyment (10·0 %).
Conclusions:Children and adolescents in the Russian Federation are likely exposed to a substantial number of unhealthy food advertisements. There is a need to consider policies to restrict children’s exposure to unhealthy food advertising on television in the Russian Federation.
The shape of and solutions to the MTurk quality crisis
- Ryan Kennedy, Scott Clifford, Tyler Burleigh, Philip D. Waggoner, Ryan Jewell, Nicholas J. G. Winter
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- Political Science Research and Methods / Volume 8 / Issue 4 / October 2020
- Published online by Cambridge University Press:
- 24 April 2020, pp. 614-629
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Amazon's Mechanical Turk is widely used for data collection; however, data quality may be declining due to the use of virtual private servers to fraudulently gain access to studies. Unfortunately, we know little about the scale and consequence of this fraud, and tools for social scientists to detect and prevent this fraud are underdeveloped. We first analyze 38 studies and show that this fraud is not new, but has increased recently. We then show that these fraudulent respondents provide particularly low-quality data and can weaken treatment effects. Finally, we provide two solutions: an easy-to-use application for identifying fraud in the existing datasets and a method for blocking fraudulent respondents in Qualtrics surveys.
Assessing diet in European populations using national dietary surveys
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- Holly L. Rippin, Jayne Hutchinson, Jo Jewell, Joao J. Breda, Janet E. Cade
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- Proceedings of the Nutrition Society / Volume 79 / Issue 4 / November 2020
- Published online by Cambridge University Press:
- 23 January 2020, pp. 531-541
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The WHO encourages countries to conduct national dietary surveys (NDS) to inform preventative policies targeting malnutrition and noncommunicable diseases. Previous reviews have found inadequate nutrient intakes and survey provision across Europe. This research is the first to provide an updated review of NDS provision within the whole WHO European Region, across the lifecourse, with reference to disadvantaged groups, obesity and nutrients of concern. Over a third of WHO European countries, mainly Central and Eastern European countries (CEEC), had no identifiable NDS. Where countries reported nutrient intakes, poor WHO recommended nutrient intake attainment was Europe-wide across the lifecourse, particularly in CEEC. Lower educated individuals had poorer diet quality. However, heterogeneity in age group sampled, dietary assessment method, nutrient composition database and under-reporting hindered inter-country comparisons. Average population trans fatty acid intakes below WHO recommended limits may hide inequalities in disadvantaged groups; legislative bans may help alleviate this. There were few associations between NDS-derived consumed food portion size (FPS) and BMI. However, consumed FPS was greater than on-pack serving-size in the majority of foods studied. This review illustrates how NDS can generate information on diet, nutrient intakes and the food environment. However, to enable valid inter-country comparisons, countries should be encouraged to conduct and report harmonised NDS, particularly in the age groups sampled, dietary assessment methodology, nutrient range, underpinning food composition database and treatment of under-reporters. This will aid effective, coordinated policy development that can have a real impact on dietary improvement, on a population and subgroup level, throughout Europe.
Child and adolescent nutrient intakes from current national dietary surveys of European populations
- Holly L. Rippin, Jayne Hutchinson, Jo Jewell, Joao J. Breda, Janet E. Cade
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- Journal:
- Nutrition Research Reviews / Volume 32 / Issue 1 / June 2019
- Published online by Cambridge University Press:
- 31 October 2018, pp. 38-69
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The WHO encourages national diet survey (NDS) implementation to obtain relevant data to inform policies addressing all forms of malnutrition, which remains a pressing issue throughout Europe. This paper provides an up-to-date review on energy, macro- and selected micronutrient intakes in children across WHO Europe using the latest available NDS intakes. It assesses these against WHO recommended nutrient intakes (RNI) to highlight vulnerable groups and areas of concern. Dietary survey information was gathered by Internet searches, contacting survey authors and nutrition experts. Survey characteristics, energy and nutrient intakes were extracted and weighted means calculated and presented by region. Child energy and nutrient intakes were extracted from twenty-one NDS across a third (n 18) of the fifty-three WHO Europe countries. Of these, 38 % (n 6) reported intakes by socio-economic group, but by various indicators. Energy and macronutrients, where boys and older children had higher intakes, were more widely reported than micronutrients. Most countries met under half of the WHO RNI for nutrients reported in their NDS. Micronutrient attainment was higher than macronutrients, but worst in girls and older children. Only a third, mainly Western, WHO European member states provided published data on child nutrient intakes. Gaps in provision mean that dietary inadequacies may go unidentified, preventing evidence-based policy formation. WHO RNI attainment was poor, particularly in girls and older children. Inconsistent age groups, dietary methodologies, nutrient composition databases and under-reporting hinder inter-country comparisons. Future efforts should encourage countries to conduct NDS in a standardised format by age and sociodemographic variables.
Energy and macronutrient intakes across the lifecourse from current national dietary surveys of European populations
- H.L. Rippin, J. Hutchinson, J. Jewell, J.J. Breda, J.E. Cade
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- Proceedings of the Nutrition Society / Volume 77 / Issue OCE4 / 2018
- Published online by Cambridge University Press:
- 05 October 2018, E127
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Portion size of energy-dense foods in French and UK adults by BMI status: is there an association between portion size and BMI?
- H.L. Rippin, J. Hutchinson, J. Jewell, J.J Breda, J.E. Cade
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- Proceedings of the Nutrition Society / Volume 77 / Issue OCE4 / 2018
- Published online by Cambridge University Press:
- 05 October 2018, E181
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Comparison of high and low trans-fatty acid consumers: analyses of UK National Diet and Nutrition Surveys before and after product reformulation
- Jayne Hutchinson, Holly L Rippin, Jo Jewell, Joao J Breda, Janet E Cade
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- Public Health Nutrition / Volume 21 / Issue 3 / February 2018
- Published online by Cambridge University Press:
- 21 November 2017, pp. 465-479
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Objective
The WHO encourages the virtual elimination of artificial trans-fatty acids (TFA), which increase CHD risk. Our UK analysis explores whether voluntary reformulation results in differential TFA intakes among socio-economic groups by determining characteristics of high TFA consumers before and after product reformulation.
DesignFood intake was collected by 7d weighed records pre-reformulation and 4d diaries post-reformulation. Sociodemographic characteristics of TFA consumers above the WHO limit, and of the top 10 % of TFA consumers as a percentage food energy, were compared with those of lower TFA consumers. Multivariate logistic regression determined independent socio-economic predictors of being a top 10 % consumer.
SubjectsUK National Diet and Nutrition Surveys (NDNS) for adults aged 19–64 years pre-reformulation (2000/01; N 1724) and post-reformulation (2010/11–2011/12; N 848).
ResultsPost-reformulation 2·5 % of adults exceeded the WHO limit, v. 57 % pre-reformulation. In unadjusted analyses, high TFA consumption was associated with lower income, lower education and long-term illness/disability pre- but not post-reformulation. In adjusted pre-reformulation analyses, degree holders were half as likely as those without qualifications to be top 10 % consumers (OR=0·51; 95 % CI 0·28, 0·92). In adjusted post-reformulation analyses, those with higher income were 2·5–3·3 times more likely to be top 10 % consumers than lowest income households. Pre-reformulation, high consumers consumed more foods containing artificial TFA, whereas ruminant TFA were more prominent post-reformulation.
ConclusionsHigh TFA consumption was associated with socio-economic disadvantage pre-reformulation, but evidence of this is less clear post-reformulation. Voluntary reformulation appeared effective in reducing TFA content in many UK products with mixed effects on dietary inequalities relating to income and education.
Stimulation parameters differ between current anti-modiolar and peri-modiolar electrode arrays implanted within the same child
- M J Polonenko, S L Cushing, K A Gordon, B Allemang, S Jewell, B C Papsin
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- Journal:
- The Journal of Laryngology & Otology / Volume 130 / Issue 11 / November 2016
- Published online by Cambridge University Press:
- 14 October 2016, pp. 1007-1021
- Print publication:
- November 2016
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Objective:
To compare stimulation parameters of peri-modiolar and anti-modiolar electrode arrays using two surgical approaches.
Methods:Impedance, stimulation thresholds, comfortably loud current levels, electrically evoked compound action potential thresholds and electrically evoked stapedial reflex thresholds were compared between 2 arrays implanted in the same child at 5 time points: surgery, activation/day 1, week 1, and months 1 and 3. The peri-modiolar array was implanted via cochleostomy in all children (n = 64), while the anti-modiolar array was inserted via a cochleostomy in 43 children and via the round window in 21 children.
Results:The anti-modiolar array had significantly lower impedance, but required higher current levels to elicit thresholds, comfort, electrically evoked compound action potential thresholds and electrically evoked stapedial reflex thresholds than the peri-modiolar array across all time points, particularly in basal electrodes (p < 0.05). The prevalence of open electrodes was similar in anti-modiolar (n = 5) and peri-modiolar (n = 3) arrays.
Conclusion:Significant but clinically acceptable differences in stimulation parameters between peri-modiolar and anti-modiolar arrays persisted four months after surgery in children using bilateral cochlear implants. The surgical approach used to insert the anti-modiolar array had no overall effect on outcomes.
Composite International Diagnostic Interview screening scales for DSM-IV anxiety and mood disorders
- R. C. Kessler, J. R. Calabrese, P. A. Farley, M. J. Gruber, M. A. Jewell, W. Katon, P. E. Keck, Jr., A. A. Nierenberg, N. A. Sampson, M. K. Shear, A. C. Shillington, M. B. Stein, M. E. Thase, H.-U. Wittchen
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- Psychological Medicine / Volume 43 / Issue 8 / August 2013
- Published online by Cambridge University Press:
- 18 October 2012, pp. 1625-1637
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Background
Lack of coordination between screening studies for common mental disorders in primary care and community epidemiological samples impedes progress in clinical epidemiology. Short screening scales based on the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI), the diagnostic interview used in community epidemiological surveys throughout the world, were developed to address this problem.
MethodExpert reviews and cognitive interviews generated CIDI screening scale (CIDI-SC) item pools for 30-day DSM-IV-TR major depressive episode (MDE), generalized anxiety disorder (GAD), panic disorder (PD) and bipolar disorder (BPD). These items were administered to 3058 unselected patients in 29 US primary care offices. Blinded SCID clinical reinterviews were administered to 206 of these patients, oversampling screened positives.
ResultsStepwise regression selected optimal screening items to predict clinical diagnoses. Excellent concordance [area under the receiver operating characteristic curve (AUC)] was found between continuous CIDI-SC and DSM-IV/SCID diagnoses of 30-day MDE (0.93), GAD (0.88), PD (0.90) and BPD (0.97), with only 9–38 questions needed to administer all scales. CIDI-SC versus SCID prevalence differences are insignificant at the optimal CIDI-SC diagnostic thresholds (χ21 = 0.0–2.9, p = 0.09–0.94). Individual-level diagnostic concordance at these thresholds is substantial (AUC 0.81–0.86, sensitivity 68.0–80.2%, specificity 90.1–98.8%). Likelihood ratio positive (LR+) exceeds 10 and LR− is 0.1 or less at informative thresholds for all diagnoses.
ConclusionsCIDI-SC operating characteristics are equivalent (MDE, GAD) or superior (PD, BPD) to those of the best alternative screening scales. CIDI-SC results can be compared directly to general population CIDI survey results or used to target and streamline second-stage CIDIs.
Chapter 5 - Energy and Security
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- By Aleh Cherp, Central European University, Adeola Adenikinju, University of Ibadan, Andreas Goldthau, Central European University, Francisco Hernandez, Lund University, Larry Hughes, Dalhousie University, Jaap Jansen, Energy Research Centre of the Netherlands, Jessica Jewell, Central European University, Marina Olshanskaya, United Nations Development Programme, Ricardo Soares de Oliveira, Oxford University, Benjamin Sovacool, National University of Singapore, Sergey Vakulenko, Cambridge Energy Research Associates, Morgan Bazilian, United Nations Industrial Development Organization, David J. Fisk, Imperial College London, Saptarshi Pal, Central European University, Ogunlade Davidson, Ministry of Energy and Water Resources
- Global Energy Assessment Writing Team
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- Global Energy Assessment
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- 05 September 2012
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- 27 August 2012, pp 325-384
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Summary
Executive Summary
Uninterrupted provision of vital energy services (see Chapter 1, Section 1.2.2) – energy security – is a high priority of every nation. Energy security concerns are a key driving force of energy policy. These concerns relate to the robustness (sufficiency of resources, reliability of infrastructure, and stable and affordable prices); sovereignty (protection from potential threats from external agents); and resilience (the ability to withstand diverse disruptions) of energy systems. Our analysis of energy security issues in over 130 countries shows that the absolute majority of them are vulnerable from at least one of these three perspectives. For most industrial countries, energy insecurity means import dependency and aging infrastructure, while many emerging economies have additional vulnerabilities such as insufficient capacity, high energy intensity, and rapid demand growth. In many low-income countries, multiple vulnerabilities overlap, making them especially insecure.
Oil and its products lack easily available substitutes in the transport sector, where they provide at least 90% of energy in almost all countries. Furthermore, the global demand for transport fuels is steadily rising, especially rapidly in Asian emerging economies. Disruptions of oil supplies may thus result in catastrophic effects on such vital functions of modern states as food production, medical care, and internal security. At the same time, the global production capacity of conventional oil is widely perceived as limited. These factors result in rising and volatile prices of oil affecting all economies, especially low-income countries, almost all of which import over 80% of their oil supplies.
Bubbles emerging from a submerged granular bed
- J. A. MEIER, J. S. JEWELL, C. E. BRENNEN, J. IMBERGER
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- Journal of Fluid Mechanics / Volume 666 / 10 January 2011
- Published online by Cambridge University Press:
- 06 January 2011, pp. 189-203
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This paper explores the phenomena associated with the emergence of gas bubbles from a submerged granular bed. While there are many natural and industrial applications, we focus on the particular circumstances and consequences associated with the emergence of methane bubbles from the beds of lakes and reservoirs since there are significant implications for the dynamics of lakes and reservoirs and for global warming. This paper describes an experimental study of the processes of bubble emergence from a granular bed. Two distinct emergence modes are identified, mode 1 being simply the percolation of small bubbles through the interstices of the bed, while mode 2 involves the cumulative growth of a larger bubble until its buoyancy overcomes the surface tension effects. We demonstrate the conditions dividing the two modes (primarily the grain size) and show that this accords with simple analytical evaluations. These observations are consistent with previous studies of the dynamics of bubbles within porous beds. The two emergence modes also induce quite different particle fluidization levels. The latter are measured and correlated with a diffusion model similar to that originally employed in river sedimentation models by Vanoni and others. Both the particle diffusivity and the particle flux at the surface of the granular bed are measured and compared with a simple analytical model. These mixing processes can be consider applicable not only to the grains themselves, but also to the nutrients and/or contaminants within the bed. In this respect they are shown to be much more powerful than other mixing processes (such as the turbulence in the benthic boundary layer) and could, therefore, play a dominant role in the dynamics of lakes and reservoirs.
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. 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- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Pork tenderness: analysis of a promoter regulating calpastatin expression
- P L Sensky, K K Jewell, C Howells, K J P Ryan, T Parr, R G Bardsley, P J Buttery
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- Proceedings of the British Society of Animal Science / Volume 2006 / March 2006
- Published online by Cambridge University Press:
- 23 November 2017, p. 21
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- March 2006
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Unpredictable variations in meat toughness in the British pig herd remain a concern to the meat industry. Whilst genetics is clearly important, 50% of this variability can be accredited to environmental factors, such as stress. At slaughter the levels of calpastatin (encoded by the CAST gene), a specific inhibitor protein that regulates the calpain proteinases largely responsible for postmortem tenderization, are strongly related to meat toughness. Down-regulation of CAST expression in the days before slaughter therefore provide a practical opportunity to reduce toughness. There are at least three CAST gene promoters (1xa, 1xb and 1u) containing transcription factor motifs sensitive to β-adrenergic stimulation, which can be induced by physiological stress (Parr et al., 2004). The 1u promoter is the predominant form in porcine muscle and the resulting CAST mRNA transcripts are increased in animals treated with the β-agonist clenbuterol (Sensky et al., 2004) or in cells treated with the analogue dibutyryl cAMP (db cAMP) (Sensky et al., 2005). In this study, the functionality of the 1u promoter is further dissected by truncation studies and mutation of potential cAMP responsive elements (CRE).
Calpastatin gene promoter activity associated with growth promoter pathways in pigs
- P. L. Sensky, K. K. Jewell, K. J. P. Ryan, T. Parr, R. G. Bardsley, P. J. Buttery
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- Proceedings of the British Society of Animal Science / Volume 2005 / 2005
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- 23 November 2017, p. 61
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- 2005
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β-agonists are known to enhance muscle growth in livestock species, although sometimes at the expense of increased meat toughness. In pigs, administration of porcine somatotropin (pST) produces muscle hypertrophy without detrimental effects on toughness. Calpastatin, a specific inhibitor that regulates the calpain proteinases responsible for cleavage of myofibrillar proteins, has a key role in growth and the rate at which meat tenderises postmortem. In the porcine calpastatin gene there are at least three calpastatin promoters (upstream of exons 1xa, 1xb and 1u respectively), of which 1u is used predominantly in skeletal muscle. All three promoters contain transcription factor binding motifs suggesting sensitivity to β-agonist/cyclic AMP (cAMP)/protein kinase A (PKA) and IGF-1/Ca2+/calcineurin-mediated signalling pathways (Parr et al., 2004). It was previously shown that expression of calpastatin mRNA from all three promoters can be increased in pigs treated with clenbuterol and suppressed in pST-treated animals (Sensky et al., 2004), suggesting differential regulation by the two pathways. In this study, the effect of manipulating these pathways is evaluated in vitro in order to determine if there is a specific element within the porcine 1u promoter that is responsive to both pathways, using rat muscle cells transfected with a series of 5’-deleted porcine 1u promoter constructs and treated with cAMP analogues and the calcium ionophore calcimycin.
Growth promoter action and calpastatin mRNA expression in porcine skeletal muscle
- P. L. Sensky, K. K. Jewell, K. J. P. Ryan, T. Parr, R. G. Bardsley, P. J. Buttery
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- Journal:
- Proceedings of the British Society of Animal Science / Volume 2004 / 2004
- Published online by Cambridge University Press:
- 20 November 2017, p. 95
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- 2004
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Studies on growth promoter action can give an insight into the mechanisms of growth control. Calpain genes encode a family of proteins responsible for calcium-dependent proteolytic activity in mammalian cells. The ubiquitous enzymes µ- and m-calpain are activated in vitro by µM and mM calcium ion concentration, respectively. Both these calpain isoforms have been implicated in myofibrillar protein turnover and are regulated by calpastatin, a highly specific inhibitor protein. Overexpression of calpastatin has been strongly associated with skeletal muscle hypertrophy and meat toughness in livestock; a plausible mechanism has been that inhibition of calpain reduces myofibrillar protein degradation while protein synthesis continues unchanged in vivo, whilst inhibition of calpain post mortem prevents proteolytic cleavage of myofibrillar proteins. In pigs there are at least three calpastatin promoters (1xa, 1xb, 1u) with transcription factor binding motifs potentially responsive to β-agonist and IGF-1/calcineurin–mediated signalling pathways (Parr et al., 2001). The objective of the current study is to compare the expression patterns of different calpastatin mRNA transcripts in pigs treated with two different classes of growth promoters: clenbuterol treatment for 24 h and porcine somatotropin (pST) for 7 d.